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Article

Familial hyperinsulinism and pancreatic beta-cell ATP-sensitive potassium channels.

Kidney international - 1 Mar 2000

Sharma N, Crane A, Gonzalez G, Bryan J, Aguilar-Bryan L

Abstract excerpt

Familial hyperinsulinism, also known as persistent hyperinsulinemic hypoglycemia of infancy (PHHI), is a genetic disease characterized by mild to severe hypoglycemia in the presence of inappropriately high levels of insulin. The recessive form is caused by mutations in the adenosine 5'-triphosphate (ATP)-sensitive K+ channel (KATP channel) present in the plasma membrane of pancreatic beta-cells. This channel is...

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Identifiers

PMID: 10720932
DOI: 10.1046/j.1523-1755.2000.00918.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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