Article
Association of HLA class-I and inhibitory KIR genotypes in Gabonese patients infected by Chikungunya or Dengue type-2 viruses.
PloS one - 1 Jan 2014
Petitdemange Caroline, Wauquier Nadia, Jacquet Jean-Michel, Theodorou Ioannis, Leroy Eric, Vieillard Vincent
Abstract excerpt
BACKGROUND: Natural killer (NK) cells provide defense in the early stages of the immune response against viral infections. Killer cell immunoglobulin-like receptors (KIR) expressed on the surface of NK cells play an important role in regulating NK cell response through recognition of human leukocyte antigen (HLA) class I molecules on target cells. Previous studies have shown that specific KIR/ligand combinations...
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