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Article

Mitochondrial reactive oxygen species generation by the SDHC V69E mutation causes low birth weight and neonatal growth retardation.

Mitochondrion - 1 Jan 2011

Ishii Takamasa, Miyazawa Masaki, Onodera Akira, Yasuda Kayo, Kawabe Noboru, Kirinashizawa Mika, Yoshimura Shinichi, Maruyama Naoki, Hartman Philip S, Ishii Naoaki

Abstract excerpt

We have previously demonstrated that excessive mitochondrial reactive oxygen species caused by mutations in the SDHC subunit of Complex II resulted in premature death in C. elegans and Drosophila, tumors in mouse cells and infertility in transgenic mice. We now report the generation and initial characterization of conditional transgenic mice (Tet-mev-1) using our uniquely developed Tet-On/Off system, which...

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Source

Identifiers

PMID: 20870041
DOI: 10.1016/j.mito.2010.09.006

Genes

SDHC

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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