XRCC1 gene polymorphism for prediction of response and prognosis in the multimodality therapy of patients with locally advanced rectal cancer.

doi:10.1016/j.jss.2010.08.002

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Article

XRCC1 gene polymorphism for prediction of response and prognosis in the multimodality therapy of patients with locally advanced rectal cancer.

The Journal of surgical research - 1 Nov 2010

Grimminger Peter P, Brabender Jan, Warnecke-Eberz Ute, Narumiya Kosuke, Wandhöfer Christoph, Drebber Uta, Bollschweiler Elfriede, Hölscher Arnulf H, Metzger Ralf, Vallböhmer Daniel

Abstract excerpt

BACKGROUND: Neoadjuvant treatment strategies have been developed to improve survival of patients with locally advanced rectal cancer. Since mainly patients with major histopathologic response benefit from this therapy, predictive markers are needed. The gene polymorphism of the X-ray-repair-cross complementing (XRCC1-) gene (rs25487) was analyzed to predict response to neoadjuvant radiochemotherapy and prognosis...

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Source

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Identifiers

PMID: 20863523
DOI: 10.1016/j.jss.2010.08.002

Genes

XRCC1

Variants

rs25487

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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