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Article

Novel single-nucleotide polymorphism markers predictive of pathologic response to preoperative chemoradiation therapy in rectal cancer patients.

International journal of radiation oncology, biology, physics - 1 Jun 2013

Kim Jin C, Ha Ye J, Roh Seon A, Cho Dong H, Choi Eun Y, Kim Tae W, Kim Jong H, Kang Tae W, Kim Seon Y, Kim Yong S

Abstract excerpt

PURPOSE: Studies aimed at predicting individual responsiveness to preoperative chemoradiation therapy (CRT) are urgently needed, especially considering the risks associated with poorly responsive patients. METHODS AND MATERIALS: A 3-step strategy for the determination of CRT sensitivity is proposed based on (1) the screening of a human genome-wide single-nucleotide polymorphism (SNP) array in correlation with...

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PMID: 23490283
DOI: 10.1016/j.ijrobp.2012.12.018

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