Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Early and sustained innate immune response defines pathology and death in nonhuman primates infected by highly pathogenic influenza virus

14 Feb 2009

Abstract excerpt

The mechanisms responsible for the virulence of the highly pathogenic avian influenza (HPAI) and of the 1918 pandemic influenza virus in humans remain poorly understood. To identify crucial components of the early host response during these infections by using both conventional and functional genomics tools, we studied 34 cynomolgus macaques (Macaca fascicularis) to compare a 2004 human H5N1 Vietnam isolate with...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Immune Response and Inflammation
Share to Influenza Virus Research Studies
Share to interferon and immune responses

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 19218453
DOI: 10.1073/pnas.0813234106

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Early and sustained innate immune response defines pathology and death in nonhuman primates infected by highly pathogenic influenza virusPMID 19218453Read ↗

Macaque Proteome Response to Highly Pathogenic Avian Influenza and 1918 Reassortant Influenza Virus InfectionsSemantic proximity Read ↗

Immunopathogenesis of lethal H5N1 avian influenza virus clade 2.3.4.4b infection in macaquesSemantic proximity Read ↗

Aberrant innate immune response in lethal infection of macaques with the 1918 influenza virusSemantic proximity Read ↗

The Multibasic Cleavage Site of the Hemagglutinin of Highly Pathogenic A/Vietnam/1203/2004 (H5N1) Avian Influenza Virus Acts as a Virulence Factor in a Host-Specific Manner in MammalsSemantic proximity Read ↗

The HA and NS genes of human H5N1 influenza A virus contribute to high virulence in ferrets.Semantic proximity Read ↗

The NS1 Protein of the 1918 Pandemic Influenza Virus Blocks Host Interferon and Lipid Metabolism PathwaysSemantic proximity Read ↗

NS1-mediated delay of type I interferon induction contributes to influenza A virulence in ferretsSemantic proximity Read ↗

Pandemic swine-origin H1N1 influenza A virus isolates show heterogeneous virulence in macaques.Semantic proximity Read ↗

Infiltration of inflammatory macrophages and neutrophils and widespread pyroptosis in lung drive influenza lethality in nonhuman primatesSemantic proximity Read ↗

Integrated Molecular Signature of Disease: Analysis of Influenza Virus-Infected Macaques through Functional Genomics and ProteomicsSemantic proximity Read ↗

Highly pathogenic avian influenza H5N1 clade 2.3.4.4b genotype B3.13 is highly virulent for mice, rapidly causing acute pulmonary and neurologic diseaseSemantic proximity Read ↗

1918 Influenza Virus Hemagglutinin (HA) and the Viral RNA Polymerase Complex Enhance Viral Pathogenicity, but Only HA Induces Aberrant Host Responses in MiceSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.