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Article

Hepatitis C virus core-derived peptides inhibit genotype 1b viral genome replication via interaction with DDX3X.

PloS one - 17 Sept 2010

Sun Chaomin, Pager Cara T, Luo Guangxiang, Sarnow Peter, Cate Jamie H D

Abstract excerpt

The protein DDX3X is a DEAD-box RNA helicase that is essential for the hepatitis C virus (HCV) life cycle. The HCV core protein has been shown to bind to DDX3X both in vitro and in vivo. However, the specific interactions between these two proteins and the functional importance of these interactions for the HCV viral life cycle remain unclear. We show that amino acids 16-36 near the N-terminus of the HCV core...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 20862261
DOI: 10.1371/journal.pone.0012826
PMCID: PMC2941470

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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