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Requirement of cellular DDX3 for hepatitis C virus replication is unrelated to its interaction with the viral core protein

30 Sept 2009

Abstract excerpt

The cellular DEAD-box protein DDX3 was recently shown to be essential for hepatitis C virus (HCV) replication. Prior to that, we had reported that HCV core binds to DDX3 in yeast-two hybrid and transient transfection assays. Here, we confirm by co-immunoprecipitation that this interaction occurs in cells replicating the JFH1 virus. Consistent with this result, immunofluorescence staining of infected cells...

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PMID: 19793905
DOI: 10.1099/vir.0.015909-0

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