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Article

MicroRNA-21 Overexpression Contributes to Vestibular Schwannoma Cell Proliferation and Survival

19 Sept 2010

Abstract excerpt

HYPOTHESIS: Elevated levels of hsa-microRNA-21 (miR-21) in vestibular schwannomas (VSs) may contribute to tumor growth by downregulating the tumor suppressor phosphatase and tensin homolog (PTEN) and consequent hyperactivation of protein kinase B (AKT), a key signaling protein in the cellular pathways that lead to tumor growth. BACKGROUND: Vestibular schwannomas are benign tumors that arise from the vestibular...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 20856158
DOI: 10.1097/mao.0b013e3181f20655

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