Article
Global profiling in vestibular schwannomas shows critical deregulation of microRNAs and upregulation in those included in chromosomal region 14q32.
PloS one - 1 Jan 2013
Torres-Martin Miguel, Lassaletta Luis, de Campos Jose M, Isla Alberto, Gavilan Javier, Pinto Giovanny R, Burbano Rommel R, Latif Farida, Melendez Barbara, Castresana Javier S, Rey Juan A
Abstract excerpt
BACKGROUND: Vestibular schwannomas are benign tumors that arise from Schwann cells in the VIII cranial pair and usually present NF2 gene mutations and/or loss of heterozygosity on chromosome 22q. Deregulation has also been found in several genes, such as ERBB2 and NRG1. MicroRNAs are non-coding RNAs approximately 21 to 23 nucleotides in length that regulate mRNAs, usually by degradation at the...
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