Article
Cuplike nuclei (prominent nuclear invaginations) in acute myeloid leukemia are highly associated with FLT3 internal tandem duplication and NPM1 mutation.
Cancer - 1 Dec 2009
Chen Weina, Konoplev Sergej, Medeiros L Jeffrey, Koeppen Hartmut, Leventaki Vasiliki, Vadhan-Raj Saroj, Jones Dan, Kantarjian Hagop M, Falini Brunangelo, Bueso-Ramos Carlos E
Abstract excerpt
BACKGROUND: A small subset of patients with acute myeloid leukemia (AML) have cuplike nuclei. Other investigators have demonstrated that these neoplasms have distinctive clinicopathologic and molecular features. METHODS: The authors searched for patients who had AML with cuplike nuclei at their institution over a 10-year interval. A strict definition for cuplike nuclei was used: >or=10% blasts with nuclear...
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