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Article

Mobility of the von Hippel-Lindau tumour suppressor protein is regulated by kinesin-2.

Experimental cell research - 1 Apr 2008

Mans Dorus A, Lolkema Martijn P, van Beest Moniek, Daenen Laura G, Voest Emile E, Giles Rachel H

Abstract excerpt

The von Hippel-Lindau tumour suppressor protein (pVHL) participates in many cellular processes including oxygen sensing, microtubule stability and primary cilia regulation. Recently, we identified ATP-dependent motor complex kinesin-2 to endogenously bind the full-length variant of VHL (pVHL30) in primary kidney cells, and mediate its association to microtubules. Here we show that pVHL also endogenously binds the...

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Source

Identifiers

PMID: 18261724
DOI: 10.1016/j.yexcr.2007.12.020

Genes

VHL

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

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Mobility of the von Hippel-Lindau tumour suppressor protein is regulated by kinesin-2.PMID 18261724Read ↗

The von Hippel-Lindau tumour suppressor interacts with microtubules through kinesin-2.Semantic proximity Read ↗

Quantitative image analysis identifies pVHL as a key regulator of microtubule dynamic instability.Semantic proximity Read ↗

Disruption of ankyrin B and caveolin-1 interaction sites alters Na <sup>+</sup> ,K <sup>+</sup> -ATPase lateral diffusion in HEK293 cell plasma membranesSemantic proximity Read ↗

ALS-associated KIF5A mutations abolish autoinhibition resulting in a toxic gain of function.Semantic proximity Read ↗

Nek1 phosphorylates Von Hippel-Lindau tumor suppressor to promote its proteasomal degradation and ciliary destabilization.Semantic proximity Read ↗

Kinesin-binding protein remodels the kinesin motor to prevent microtubule-bindingSemantic proximity Read ↗

A systems-level proteomic analysis identifies kinesin targets of KIFBP during neuronal developmentSemantic proximity Read ↗

Pathogenic KIF1A R350 Variants Disrupt A Conserved Kinesin-Tubulin Salt BridgeSemantic proximity Read ↗

Disruption of Ankyrin B and Caveolin-1 Interaction Sites Alters Na+,K+-ATPase Membrane Diffusion.Semantic proximity Read ↗

Pathogenic KIF1A R350 mutations disrupt a conserved and conformation-dependent kinesin-tubulin salt bridge.Semantic proximity Read ↗

Tubulin CFEOM mutations both inhibit or activate kinesin motor activity.Semantic proximity Read ↗

A highly conserved 310 helix within the kinesin motor domain is critical for kinesin function and human health.Semantic proximity Read ↗

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