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Article

Emodin triggers DNA double-strand breaks by stabilizing topoisomerase II-DNA cleavage complexes and by inhibiting ATP hydrolysis of topoisomerase II.

Toxicological sciences : an official journal of the Society of Toxicology - 1 Dec 2010

Li Yan, Luan Yang, Qi Xinming, Li Ming, Gong Likun, Xue Xiang, Wu Xiongfei, Wu Yuanfeng, Chen Min, Xing Guozhen, Yao Jun, Ren Jin

Abstract excerpt

Emodin, an anthraquinone derived from a plant and fungi, has been reported to possess potential genotoxicity, but the mechanism is not entirely clear. Here, we report that emodin causes DNA double-strand breaks (DSBs) through stabilization of topoisomerase (Topo) II-DNA cleavage complexes and inh...

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Identifiers

PMID: 20855424
DOI: 10.1093/toxsci/kfq282

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20855424-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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