Article
Genetic polymorphism of CYP2D6∗2 C→T 2850, GSTM1, NQO1 genes and their correlation with biomarkers in manganese miners of Central India.
Chemosphere - 1 Nov 2010
Vinayagamoorthy Nadimuthu, Krishnamurthi Kannan, Devi Sivanesan Saravana, Naoghare Pravin K, Biswas Raka, Biswas Arup R, Pramanik Sreemanta, Shende Ashok R, Chakrabarti Tapan
Abstract excerpt
Manganese (Mn) intoxication is most often regarded as an occupational manifestation and occurs in places such as manganese mines, dry cell battery plants and ceramic industries. In the present study, the influence of genetic polymorphism in cytochrome P450 2D6 (CYP2D6∗2), glutathione S-transferase M1 (GSTM1) and NAD(P)H quinone oxidoreductase 1 (NQO1) genes on blood manganese and plasma prolactin concentrations...
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