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Article

Oxygen activation by P450(cin): Protein and substrate mutagenesis.

Archives of biochemistry and biophysics - 1 Mar 2011

Slessor Kate E, Farlow Anthony J, Cavaignac Sonia M, Stok Jeanette E, De Voss James J

Abstract excerpt

A conserved threonine found in the majority of cytochromes P450 (P450s) has been implicated in the activation of dioxygen during the catalytic cycle. P450(cin) (CYP176A) has been found to be an exception to this paradigm, where the conserved threonine has been replaced with an asparagine. Prior studies with a P450(cin) N242A mutant established that the Asn-242 was not a functional replacement for the conserved...

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Identifiers

PMID: 20851096
DOI: 10.1016/j.abb.2010.09.009

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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