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Effective Optimization of Antibody Affinity by Phage Display Integrated with High-Throughput DNA Synthesis and Sequencing Technologies

5 Jun 2015

Abstract excerpt

Phage display technology has been widely used for antibody affinity maturation for decades. The limited library sequence diversity together with excessive redundancy and labour-consuming procedure for candidate identification are two major obstacles to widespread adoption of this technology. We hereby describe a novel library generation and screening approach to address the problems. The approach started with the...

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Share to Glycosylation and Glycoproteins Research
Share to Monoclonal and Polyclonal Antibodies Research
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PMID: 26046845
DOI: 10.1371/journal.pone.0129125

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