Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

High-risk HPV E5-induced cell fusion: a critical initiating event in the early stage of HPV-associated cervical cancer

16 Sept 2010

Abstract excerpt

BACKGROUND: Cervical cancer is strongly associated with high-risk human papillomavirus (HPV) and viral oncoproteins E5, E6 and E7 can transform cells by various mechanisms. It is proposed that oncogenic virus-induced cell fusion may contribute to oncogenesis if p53 or apoptosis is perturbed simultaneously. Recently, HPV-16 E5 was found to be necessary and sufficient for the formation of tetraploid cells, which...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer-related Molecular Pathways
Share to Cervical Cancer and HPV Research
Share to Endometrial and Cervical Cancer Treatments

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 20846406
DOI: 10.1186/1743-422x-7-238

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

High-risk HPV E5-induced cell fusion: a critical initiating event in the early stage of HPV-associated cervical cancerPMID 20846406Read ↗

Historical perspective of cell-cell fusion in cancer initiation and progression.Semantic proximity Read ↗

Human papillomavirus 16 E5 induces bi-nucleated cell formation by cell–cell fusionSemantic proximity Read ↗

Cellular Functions of HPV16 E5 Oncoprotein during Oncogenic TransformationSemantic proximity Read ↗

Expression of HPV oncogenes from a single integration site in cervical cancer cell linesSemantic proximity Read ↗

Human Papillomavirus E7 Induces Rereplication in Response to DNA DamageSemantic proximity Read ↗

Centrosomes, Genomic Instability, and Cervical CarcinogenesisSemantic proximity Read ↗

Co-expression of Low-risk HPV E6/E7 and EBV LMP-1 Leads to Precancerous Lesions by DNA DamageSemantic proximity Read ↗

Cell Fusion is a Potent Inducer of Aneuploidy and Drug Resistance in Tumor Cell/ Normal Cell HybridsSemantic proximity Read ↗

Apoptotic HPV Positive Cancer Cells Exhibit Transforming PropertiesSemantic proximity Read ↗

An In vitro Multistep Carcinogenesis Model for Human Cervical CancerSemantic proximity Read ↗

DNA Aneuploidy and Integration of Human Papillomavirus Type 16 E6/E7 Oncogenes in Intraepithelial Neoplasia and Invasive Squamous Cell Carcinoma of the Cervix UteriSemantic proximity Read ↗

Abrogation of the Postmitotic Checkpoint Contributes to Polyploidization in Human Papillomavirus E7-Expressing CellsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.