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Article

Centrosomes, Genomic Instability, and Cervical Carcinogenesis

1 Jan 2003

Abstract excerpt

High-risk human papillomavirus (HPV)-associated carcinogenesis of the uterine cervix is a particularly useful model to study basic mechanisms of genomic instability in cancer. Cervical carcinogenesis is associated with the expression of two high-risk HPV-encoded oncoproteins, E6 and E7. Aneuploidy, the most frequent form of genomic instability in human carcinomas, develops as early as in nonmalignant cervical...

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PMID: 12839094
DOI: 10.1615/critreveukaryotgeneexpr.v13.i1.20

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