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Article

Apoptotic HPV Positive Cancer Cells Exhibit Transforming Properties

4 May 2012

Abstract excerpt

Previous studies have shown that DNA can be transferred from dying engineered cells to neighboring cells through the phagocytosis of apoptotic bodies, which leads to cellular transformation. Here, we provide evidence of an uptake of apoptotic-derived cervical cancer cells by human mesenchymal cells. Interestingly, HeLa (HPV 18+) or Ca Ski (HPV16+) cells, harboring integrated high-risk HPV DNA but not C-33 A cells...

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PMID: 22574222
DOI: 10.1371/journal.pone.0036766

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