Article
On the traces of XPD: cell cycle matters - untangling the genotype-phenotype relationship of XPD mutations
15 Sept 2010
Abstract excerpt
Mutations in the human gene coding for XPD lead to segmental progeria - the premature appearance of some of the phenotypes normally associated with aging - which may or may not be accompanied by increased cancer incidence. XPD is required for at least three different critical cellular functions: in addition to participating in the process of nucleotide excision repair (NER), which removes bulky DNA lesions, XPD...
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