Article
Conceptual thinking for in silico prioritization of candidate disease genes.
Methods in molecular biology (Clifton, N.J.) - 1 Jan 2011
Tiffin Nicki
Abstract excerpt
Prioritization of most likely etiological genes entails predicting and defining a set of characteristics that are most likely to fit the underlying disease gene and scoring candidates according to their fit to this "perfect disease gene" profile. This requires a full understanding of the disease phenotype, characteristics, and any available data on the underlying genetics of the disease. Public databases provide...
Topics
- Computer Simulation
- Data Mining
- Databases, Genetic
- Genetic Association Studies
- Genetic Predisposition to Disease
- Humans
- Models, Genetic