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Detection and quantification of mRNA in single human polar bodies: a minimally invasive test of gene expression during oogenesis

12 Sept 2010

Abstract excerpt

Proteins and mRNA produced in oogenesis support embryonic development until the zygotic transition, 3 days after fertilization. Since polar bodies can be biopsied with little if any harm to the oocyte, we tested the hypothesis that mRNA originating from expression in the meiotic oocyte is present and detectable in a single polar body prior to insemination. Human oocytes were obtained from patients undergoing...

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PMID: 20837506
DOI: 10.1093/molehr/gaq077

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