Article
Cartilage oligomeric matrix protein-angiopoientin-1 enhances angiogenesis of isolated islet and maintains normoglycemia following transplantation.
Transplantation proceedings - 1 Sept 2010
Park K S, Shim E Y, Choi B K, Moon C, Kim S H, Kim Y S, Kwon C H, Joh J W, Koh G Y, Kim S J
Abstract excerpt
Islet transplantation (ITx) has potential as a therapy for patients with type 1 diabetes. For successful engraftment and insulin independence, the transplanted islets must establish an adequate, stable blood supply. Angiopoientin-1 (Ang1) is a specific growth factor that induces vascularization via the Tie2 or Tie1 receptor. In this study, we used an in vitro angiogenesis assay to evaluate islet function...
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