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Article

Superantigenic activity is responsible for induction of coronary arteritis in mice: an animal model of Kawasaki disease

26 Dec 2002

Abstract excerpt

Kawasaki disease (KD) is a multisystem vasculitis and the leading cause of acquired heart disease in children of the developed world. Lactobacillus casei cell wall extract-induced coronary arteritis in mice mirrors KD in children. Here, we report that responses to L. casei cell wall extract possess all the hallmarks of a superantigen-mediated response: marked proliferation of naive T cells, non-classical major...

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PMID: 12502728
DOI: 10.1093/intimm/dxg007

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