Article
Comparison of multimarker logistic regression models, with application to a genomewide scan of schizophrenia.
BMC genetics - 9 Sept 2010
Wason James M S, Dudbridge Frank
Abstract excerpt
BACKGROUND: Genome-wide association studies (GWAS) are a widely used study design for detecting genetic causes of complex diseases. Current studies provide good coverage of common causal SNPs, but not rare ones. A popular method to detect rare causal variants is haplotype testing. A disadvantage of this approach is that many parameters are estimated simultaneously, which can mean a loss of power and slower...
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