Article
The role of cis dimerization of signal regulatory protein alpha (SIRPalpha) in binding to CD47.
The Journal of biological chemistry - 3 Dec 2010
Lee Winston Y, Weber Dominique A, Laur Oskar, Stowell Sean R, McCall Ingrid, Andargachew Rakieb, Cummings Richard D, Parkos Charles A
Abstract excerpt
Interaction of SIRPα with its ligand, CD47, regulates leukocyte functions, including transmigration, phagocytosis, oxidative burst, and cytokine secretion. Recent progress has provided significant insights into the structural details of the distal IgV domain (D1) of SIRPα. However, the structural roles of proximal IgC domains (D2 and D3) have been largely unstudied. The high degree of conservation of D2 and D3...
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