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Article

SIRPbeta1 is expressed as a disulfide-linked homodimer in leukocytes and positively regulates neutrophil transepithelial migration.

The Journal of biological chemistry - 28 Oct 2005

Liu Yuan, Soto Ileana, Tong Qiao, Chin Alex, Bühring Hans-Jörg, Wu Tao, Zen Ke, Parkos Charles A

Abstract excerpt

Signal regulatory proteins (SIRPs) comprise a family of cell surface signaling receptors differentially expressed in leukocytes and the central nervous system. Although the extracellular domains of SIRPs are highly similar, classical motifs in the cytoplasmic or transmembrane domains distinguish them as either activating (beta) or inhibitory (alpha) isoforms. We reported previously that human neutrophils...

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PMID: 16081415
DOI: 10.1074/jbc.M506419200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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