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Article

Genetic variation in the peroxisome proliferator activated receptor-gamma gene is associated with histologically advanced NAFLD.

Digestive diseases and sciences - 1 Apr 2012

Gawrieh Samer, Marion Miranda C, Komorowski Richard, Wallace James, Charlton Michael, Kissebah Ahmed, Langefeld Carl D, Olivier Michael

Abstract excerpt

BACKGROUND: The peroxisome proliferator activated receptor-gamma (PPARG) is a nuclear receptor that regulates adipocyte differentiation, insulin sensitivity and lipid metabolism, thus, it represents a good candidate gene for non-alcoholic fatty liver disease (NAFLD). PURPOSE AND METHOD: We investigated the association of two PPARG variants (Pro12Ala and C1431T) with NAFLD and its histological features. DNA was...

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Source

Identifiers

PMID: 22160635
DOI: 10.1007/s10620-011-1994-2

Genes

PPARG

Variants

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