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Article

PRKAR1A is overexpressed and represents a possible therapeutic target in human cholangiocarcinoma

8 Sept 2010

Abstract excerpt

The protein kinase A regulatory subunit 1 alpha (PRKAR1A/PKAI) pathway is overexpressed in varieties of tumors and cancer cell lines including cholangiocarcinoma (CCA), although its role in CCA growth modulation is unclear. In our study, we evaluated the effect of PRKAR1A/PKAI targeting on CCA cell proliferation. Real-time PCR demonstrated an increased mRNA expression of PRKAR1A/PKAI, whereas protein kinase A...

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PMID: 20824711
DOI: 10.1002/ijc.25646

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