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Article

Therapeutic and Predicted Significance of PKLR in Patients With Cholangiocarcinoma.

Cancer reports (Hoboken, N.J.) - 1 Aug 2026

Gong Biyan, Xu Xuejun, Xu Tubing, Zhang Dong, Yang Li, Li Cailing, Li Tingjun, Luo Yuandeng

Abstract excerpt

BACKGROUND: Cholangiocarcinoma (CCA) is a highly heterogeneous malignancy with a poor prognosis. However, the molecular mechanisms underlying CCA and its treatment options remain unclear and limited. AIMS: This study aims to identify novel prognostic biomarkers and potential therapeutic targets for CCA through transcriptomics and whole-exome sequencing analysis. METHODS AND RESULTS: We analyzed the relationship...

Topics

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Bile Duct Neoplasms
Biomarkers, Tumor
Cell Line, Tumor
Cholangiocarcinoma
Exome Sequencing

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Gene Expression Profiling

Gene Expression Regulation, Neoplastic

Source

Open in PubMed Open full text

Identifiers

PMID: 42599115
DOI: 10.1002/cnr2.70649
PMCID: PMC13475273

Genes

PKLR
ARID1A
KRAS
FOLH1
KCNH2
LCN2
MMP10
PORCN
PTH1R
RIPK3
SRPK3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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