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Increased Expression of Bcl11b Leads to Chemoresistance Accompanied by G1 Accumulation

2 Sept 2010

Abstract excerpt

BACKGROUND: The expression of BCL11B was reported in T-cells, neurons and keratinocytes. Aberrations of BCL11B locus leading to abnormal gene transcription were identified in human hematological disorders and corresponding animal models. Recently, the elevated levels of Bcl11b protein have been described in a subset of squameous cell carcinoma cases. Despite the rapidly accumulating knowledge concerning Bcl11b...

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PMID: 20824091
DOI: 10.1371/journal.pone.0012532

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