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Article

A six-generation Chinese family in haplogroup B4C1C exhibits high penetrance of 1555A > G-induced hearing Loss.

BMC medical genetics - 7 Sept 2010

Bai Yan, Wang Zhengmin, Dai Wenjia, Li Qingzhong, Chen Guoling, Cong Ning, Guan Minxin, Li Huawei

Abstract excerpt

BACKGROUND: The 1555A > G mutation is the most common cause of aminoglycoside-induced and non-syndromic deafness. However, the variable clinical phenotype and incomplete penetrance of A1555G-induced hearing loss complicate our understanding of this mutation. Environmental factors, nuclear genes, mitochondrial haplotypes/variants and a possible threshold effect have been reported to may be involved in its...

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Identifiers

PMID: 20822538
DOI: 10.1186/1471-2350-11-129
PMCID: PMC2944124

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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