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Article

Very low penetrance of hearing loss in seven Han Chinese pedigrees carrying the deafness-associated 12S rRNA A1555G mutation.

Gene - 15 May 2007

Tang Xiaowen, Yang Li, Zhu Yi, Liao Zhisu, Wang Jindan, Qian Yaping, Tao Zhihua, Hu Lenong, Wu Guomin, Lan Jinshan, Wang Xinjian, Ji Jingzhang, Wu Jian, Ji Yu, Feng Jinbao, Chen Jianfu, Li Zhiyuan, Zhang Xue, Lu Jianxin, Guan Min-Xin

Abstract excerpt

Mutations in mitochondrial DNA (mtDNA) have been found to be associated with sensorineural hearing loss. We report here the clinical, genetic and molecular characterizations of seven Han Chinese pedigrees with aminoglycoside-induced and nonsyndromic bilateral hearing loss. Clinical evaluation revealed the variable phenotype of hearing impairment including severity, age-at-onset and audiometric configuration in...

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PMID: 17341440
DOI: 10.1016/j.gene.2007.01.001

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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