Article
A gradient of NOS1 overproduction alleles in European and Mediterranean populations.
Genetic testing and molecular biomarkers - 1 Oct 2010
Piras Ignazio, Falchi Alessandra, Moral Pedro, Paoli Giorgio, Calò Carla Maria, Vona Giuseppe, Varesi Laurent
Abstract excerpt
AIM: A (CA)n repeat located in the 3' UTR region of exon 29 of the NOS1 gene (encoding for neuronal nitric oxide synthase) has been shown to affect the size of mRNA. NOS1 mRNA is highly diverse, contributing to changes in transcript generation, degradation, processing, or subcellular targeting. In the present work, we analyzed allele frequencies of this (CA)n repeat in nine populations of the Mediterranean area...
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