Physiologic and pathologic abnormalities in severe asthma.

Abstract excerpt

Severe asthma remains poorly understood and frustrating to treat, partly because it is a heterogeneous disease. Recent improvements in the definition of severe asthma have allowed better characterization of the phenotypes of severe asthma and the related physiologic and pathologic abnormalities. Early-onset severe asthma is a more allergy-associated disease than late-onset asthma. Persistent eosinophilia is more...

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