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Article

Genetic variations and haplotypes in TIM-3 gene and the risk of gastric cancer.

Cancer immunology, immunotherapy : CII - 1 Dec 2010

Cao Bangwei, Zhu Linzhong, Zhu Shengtao, Li Danping, Zhang Chuanzhen, Xu Changqing, Zhang Shutian

Abstract excerpt

PURPOSE: T cell immunoglobulin and mucin domain-containing molecule 3 (TIM-3) could weaken the Th1-mediated anti-tumor responses and accelerate the tumor cell proliferation by inhabiting the production of IL-2 or IFN-γ. This study was to assess the association between TIM-3 genetic variations and the development of gastric cancer. PATIENTS AND METHODS: Five polymorphisms located in the promoter or encoding region...

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Identifiers

PMID: 20811886
DOI: 10.1007/s00262-010-0910-5
PMCID: PMC11030773

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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