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Article

Hypertrophic cardiomyopathy-associated mutations drive stromal activation via EGFR-mediated paracrine signaling.

Science advances - 18 Oct 2024

Ewoldt Jourdan K, Wang Miranda C, McLellan Micheal A, Cloonan Paige E, Chopra Anant, Gorham Joshua, Li Linqing, DeLaughter Daniel M, Gao Xining, Lee Joshua H, Willcox Jon A L, Layton Olivia, Luu Rebeccah J, Toepfer Christopher N, Eyckmans Jeroen, Seidman Christine E, Seidman Jonathan G, Chen Christopher S

Abstract excerpt

Hypertrophic cardiomyopathy (HCM) is characterized by thickening of the left ventricular wall, diastolic dysfunction, and fibrosis, and is associated with mutations in genes encoding sarcomere proteins. While in vitro studies have used human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) to study HCM, these models have not examined the multicellular interactions involved in fibrosis. Using...

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Share to Cardiac Myosins
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Induced Pluripotent Stem Cells

Share to Myocytes, Cardiac

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Source

Open in PubMed Open full text

Identifiers

PMID: 39413182
DOI: 10.1126/sciadv.adi6927
PMCID: PMC11482324

Genes

MYH7
EGFR
MYBPC3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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