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Article

Involvement of mitophagy in cisplatin-induced cell death regulation

20 Jun 2018

Abstract excerpt

Mitophagy, the selective degradation of mitochondria via the autophagic pathway, is a vital mechanism of mitochondrial quality control in cells. The removal of malfunctioning or damaged mitochondria is essential for normal cellular physiology and tissue development. Stimulation of mitochondrial permeabilization and release of proapoptotic factors from the intermembrane space is an essential step in triggering the...

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PMID: 29924729
DOI: 10.1515/hsz-2018-0210

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