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Article

The PPCD1 mouse: characterization of a mouse model for posterior polymorphous corneal dystrophy and identification of a candidate gene.

PloS one - 16 Aug 2010

Shen Anna L, O'Leary Kathleen A, Dubielzig Richard R, Drinkwater Norman, Murphy Christopher J, Kasper Charles B, Bradfield Christopher A

Abstract excerpt

The PPCD1 mouse, a spontaneous mutant that arose in our mouse colony, is characterized by an enlarged anterior chamber resulting from metaplasia of the corneal endothelium and blockage of the iridocorneal angle by epithelialized corneal endothelial cells. The presence of stratified multilayered corneal endothelial cells with abnormal patterns of cytokeratin expression are remarkably similar to those observed in...

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Share to Chromosomes, Mammalian
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Corneal Diseases

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Source

Open in PubMed Open full text

Identifiers

PMID: 20808945
DOI: 10.1371/journal.pone.0012213
PMCID: PMC2922377

Genes

ZEB1

Provenance

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