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Article

Transcriptomic Profiling of Posterior Polymorphous Corneal Dystrophy

27 Jun 2017

Abstract excerpt

Purpose: To investigate the molecular basis of posterior polymorphous corneal dystrophy (PPCD) by examining the PPCD transcriptome and the effect of decreased ZEB1 expression on corneal endothelial cell (CEnC) gene expression. Methods: Next-generation RNA sequencing (RNA-seq) analyses of corneal endothelium from two PPCD-affected individuals (one with PPCD3 and one of unknown genetic cause) compared with two...

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PMID: 28654985
DOI: 10.1167/iovs.17-21423

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