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Article

A Novel Cas Family Member, HEPL, Regulates FAK and Cell Spreading

7 Feb 2008

Abstract excerpt

For over a decade, p130Cas/BCAR1, HEF1/NEDD9/Cas-L, and Efs/Sin have defined the Cas (Crk-associated substrate) scaffolding protein family. Cas proteins mediate integrin-dependent signals at focal adhesions, regulating cell invasion and survival; at least one family member, HEF1, regulates mitosis. We here report a previously undescribed novel branch of the Cas protein family, designated HEPL (for...

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PMID: 18256281
DOI: 10.1091/mbc.e07-09-0953

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