Article
Quantitative sequence-kinetics relationship in antigen-antibody interaction kinetics based on a set of descriptors [corrected].
Chemical biology & drug design - 1 Oct 2010
Rong-Kai Xie, Hai-Xia Long, Xiao-Ming Cheng, Yuan-Qiang Wang, Yong Lin, Ying Yang, Bo Zhu, Zhi-Hua Lin
Abstract excerpt
The interaction between recombinant Fab57P and the coat protein of tobacco mosaic virus was studied using quantitative structure-activity relationship (QSAR) method. The development of quantitative multivariate model has shown to be a promising approach for unraveling protein-protein interactions by designed mutations in peptide sequence. This approach makes it possible to stereo-chemically determine which...
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