Structural modeling extends QSAR analysis of antibody-lysozyme interactions to 3D-QSAR.

Abstract excerpt

This work shows that quantitative multivariate modeling is an emerging possibility for unraveling protein-protein interactions using a combination of designed mutations with sequence and structure information. Using this approach, it is possible to stereochemically determine which residue properties contribute most to the interaction. This is illustrated by results from modeling of the interaction of the...

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