Article
Characterisation of the phenotype and function of monocyte-derived dendritic cells in allergic conjunctiva.
The British journal of ophthalmology - 1 Dec 2010
Manzouri Bita, Ohbayashi Masaharu, Leonardi Andrea, Fattah Dilniya, Larkin Daniel F P, Ono Santa J
Abstract excerpt
BACKGROUND: Dendritic cells (DCs) are the most potent antigen-presenting cells involved in initiating the immune response, presenting antigens to T cells and leading to T cell proliferation. In an immature state, DCs lack accessory signals required for T cell stimulation but are highly specialised to capture antigens. Full DC maturation changes the cell surface phenotype and facilitates stimulation of T cell...
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