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Article

SRD5A2 is associated with increased cortisol metabolism in schizophrenia spectrum disorders.

Progress in neuro-psychopharmacology & biological psychiatry - 1 Dec 2010

Steen Nils Eiel, Tesli Martin, Kähler Anna K, Methlie Paal, Hope Sigrun, Barrett Elizabeth A, Larsson Sara, Mork Erlend, Løvås Kristian, Røssberg Jan Ivar, Agartz Ingrid, Melle Ingrid, Djurovic Srdjan, Lorentzen Steinar, Berg Jens P, Andreassen Ole A

Abstract excerpt

OBJECTIVE: Dysfunction of the hypothalamic-pituitary-adrenal (HPA) axis is documented in bipolar disorder and schizophrenia, but the mechanism is unclear; recently, increased activity of cortisol metabolizing enzymes was indicated in these disorders. We investigated whether five genes involved in cortisol metabolism were associated with altered activity of cortisol metabolizing enzymes in bipolar disorder (BD)...

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Identifiers

PMID: 20800085
DOI: 10.1016/j.pnpbp.2010.08.013

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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