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Article

Adenosine Hypothesis of Antipsychotic Drugs Revisited: Pharmacogenomics Variation in Nonacute Schizophrenia.

Omics : a journal of integrative biology - 1 May 2016

Turčin Arijana, Dolžan Vita, Porcelli Stefano, Serretti Alessandro, Plesničar Blanka Kores

Abstract excerpt

The existing antipsychotic therapy is based on dopamine hyperfunction and glutamate hypofunction hypotheses of schizophrenia. Adenosine receptors (ADORA) have a neuromodulatory role and can control dopaminergic and glutamatergic systems. To elucidate the effect of ADORA polymorphisms on psychopathological symptoms and adverse effects in patients with schizophrenia on long-term antipsychotic treatment, we examined...

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Source

Identifiers

PMID: 27195966
DOI: 10.1089/omi.2016.0003

Genes

ADORA1
ADORA3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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