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Article

Evaluation of Adenosine A2A receptor gene polymorphisms as risk factors of methamphetamine use disorder susceptibility and predictors of craving degree.

Psychiatry research - 1 Oct 2022

Wang Huiying, Ma Yitian, Wang Xiaochen, Zhang Wenpei, Han Wei, Liu Haobiao, Li Miao, Xiao Jing, Wei Hang, Wang Changqing, Sindhwani Shria, Zhang Tianxiao, Guan Fanglin, Rice John P

Abstract excerpt

The adenosine A2A receptor (ADORA2A) is highly expressed in the central nervous system and plays vital roles in drug addiction. In this study, we aimed to explore the susceptibility of ADORA2A to methamphetamine use disorder (MUD) and the craving degree based on a two-stage association analysis. A total of 3,542 (1,216 patients with MUD and 2,326 controls) and 1,740 participants (580 patients with MUD and 1,160...

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PMID: 35987070
DOI: 10.1016/j.psychres.2022.114790

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