Article
Two Novel Salmonella Bivalent Vaccines Confer Dual Protection against Two Salmonella Serovars in Mice.
Frontiers in cellular and infection microbiology - 1 Jan 2017
Zhao Xinxin, Dai Qinlong, Jia Renyong, Zhu Dekang, Liu Mafeng, Wang Mingshu, Chen Shun, Sun Kunfeng, Yang Qiao, Wu Ying, Cheng Anchun
Abstract excerpt
Non-typhoidal Salmonella includes thousands of serovars that are leading causes of foodborne diarrheal illness worldwide. In this study, we constructed three bivalent vaccines for preventing both Salmonella Typhimurium and Salmonella Newport infections by using the aspartate semialdehyde dehydrogenase (Asd)-based balanced-lethal vector-host system. The constructed Asd+ plasmid pCZ11 carrying a subset of the...
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