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Article

Generation and evaluation of Salmonella entericaserovar Choleraesuis mutant strains as a potential live-attenuated vaccine.

Vaccine - 24 Oct 2024

Huang Xin, Yang Shanshan, Zhao Jing, Yang Jing, Jiang Huazheng, Li Shuxian, Wang Caiying, Liu Guangliang

Abstract excerpt

BACKGROUND: Salmonella entericaserovar Choleraesuis (S.C) is a swine enteric pathogen causing paratyphoid fever, enterocolitis, and septicemia in piglets. S. C is mainly transmitted through the fecal-oral route. Vaccination is an effective strategy for preventing and controlling Salmonella infection. RESULTS: Herein, we used CRISPR-Cas9 technology to knockout the virulence regulatory genes, rpoS, and slyA of S. C...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 39197218
DOI: 10.1016/j.vaccine.2024.126262

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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