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Article

IL-6-mediated intersubgenotypic variation of interferon sensitivity in hepatitis C virus genotype 2a/2b chimeric clones.

Virology - 10 Nov 2010

Suda Goki, Sakamoto Naoya, Itsui Yasuhiro, Nakagawa Mina, Tasaka-Fujita Megumi, Funaoka Yusuke, Watanabe Takako, Nitta Sayuri, Kiyohashi Kei, Azuma Seishin, Kakinuma Sei, Tsuchiya Kiichiro, Imamura Michio, Hiraga Nobuhiko, Chayama Kazuaki, Watanabe Mamoru

Abstract excerpt

Mechanisms of difference in interferon sensitivity between hepatitis C virus (HCV) strains have yet to be clarified. Here, we constructed an infectious genotype2b clone and analyzed differences in interferon-alpha sensitivity between HCV-2b and 2a-JFH1 clones using intergenotypic homologous recombination. The HCV-2b/JFH1 chimeric virus able to infect Huh7.5.1 cells and was significantly more sensitive to IFN than...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 20797756
DOI: 10.1016/j.virol.2010.07.041

Genes

SOCS3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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